CONTENTS
- What are NMN and Resveratrol?
- Why they should be taken together
- Other important benefits of NMN and Resveratrol
What are NMN and Resveratrol?
NAD+ (Nicotinamide adenine dinucleotide) is an essential coenzyme for supporting fundamental biological processes.
From energy generation to DNA repair, NAD+ plays a critical role in maintaining cellular health and promoting longevity.
In the body, NMN is converted to NAD+ by an enzymatic process.
This conversion is extremely important for maintaining adequate levels of NAD+ in cells.
It is even more important as we age and natural production of NAD+ decreases.
There are many studies suggesting that NMN may support cellular functions by increasing NAD+ levels, which may have beneficial effects on cellular energy, mitochondrial health and longevity.
NMN may also help improve insulin sensitivity and cardiovascular function.
Resveratrol is an antioxidant with numerous health benefits, which can be found in various foods, but can also be taken in the form of dietary supplements.
Although it is not a direct precursor of NAD+, it is commonly used in combination with NAD+ supplements because of its synergistic benefits.
Resveratrol helps protect mitochondria against oxidative stress and improves their function.
This is essential for energy production in cells.
Why they should be taken together
A study conducted in China showed that NMN combined with Resveratrol synergistically stimulates NAD+ in the heart and skeletal muscles of mice, while combining NMN with ginsenoside boosts NAD+ in the lungs.
If we compare with administration of NMN alone, combining NMN with Resveratrol increases NAD+ in the heart and muscle by 1.59-fold and 1.72-fold, respectively.
[1] Recent studies have highlighted the potential benefits of these two compounds when used together.
Other important benefits of NMN and Resveratrol
Resveratrol also has great potential in improving cardiovascular function.
One study investigated the cardioprotective effects of Resveratrol, including its antioxidant and anti-inflammatory properties [2].
A study in Science Journal found that NMN supplementation improved insulin sensitivity in muscle.
The research included prediabetic women, highlighting its potential role in metabolic health [3].
Resveratrol activates the SIRT1/PGC-1 pathway, improving cognitive function after traumatic brain injury [4].
This neuroprotective effect, combined with NMN’s potential to enhance cellular energy production, could provide a synergistic approach to protect against neurodegenerative diseases and cognitive decline associated with aging.
The anti-inflammatory and antioxidant properties of resveratrol suggest its important role in attenuating oxidative stress and inflammation, which are key factors in ageing [5].
When combined with NMN, which enhances NAD+ levels, there is a potential for enhanced protection against age-related oxidative damage. SOURCES: [1] – Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol [2] – Pharmacological basis and new insights of resveratrol action in the cardiovascular system [3] – Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women [4] – Resveratrol Activates the SIRT1/PGC-1 Pathway in Mice to Improve Synaptic-Related Cognitive Impairment after TBI [5] – Anti-Inflammatory Action and Mechanisms of Resveratrol
